三、主要科研工作与成绩 Wan G, Liu Y, Zhu J, Guo L, Li C, Yang Y, Gu X, Deng LL*, Lu C.* SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/ β-catenin pathway.Cell Signal .2019 Mar 4;59:1-12; 李锦宏，陈兵*，顾雪锋*，马国达，杨帆，高力扬，廖壮槟，林亨，龙霄翱.乙二醛酶1在脑胶质瘤组织中的表达. 广东医学院学报.2016.10;34(5):480-483; 黄文辉，顾雪锋，李克深*. 微小RNA在神经退行性疾病发病机制中作用的研究进展.山东医药.2016;56(41):106-109. Gu X, Wang C, Wang X, Ma G, Li Y, Cui L, Chen Y, Zhao B*, Li K*. Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5.Int J Biol Sci.11(2):230-7. 2015 Jan; Gu X, Yao L, Ma G, Cui L, Li Y, Liang W, Zhao B*, Li K*. TCTP promotes glioma cell proliferation in vitro and in vivo via enhanced β-catenin/TCF-4 transcription. Neuro Oncol.16(2):217-27. 2014 Jan; Gu X, Wang X, Xiao H, Ma G,Cui L,Li Y, Zhou H, Liang W, Zhao B*, Li K*.Silencing of R-Spondin1 increases radiosensitivity of glioma cells.Oncotarget. 2015 Apr 30; 6(12): 9756–9765; Ma G, Wang H, Gu X, Li W, Zhang X, Cui L, Li Y, Zhang Y, Zhao B*,Li K*. CARP, a Myostatin-down regulated gene in CFM cells, is a novel essential positive regulator of myogenesis.Int J Biol Sci. 10(3):309-20. 2014 Mar; Li Y, Yang C, Ma G, Cui L, Gu X, Chen Y, Zhao B, Wang H, Li K*. Analysis of ADAM17 polymorphisms and susceptibility to sporadic abdominal aortic aneurysm. Cell Physiol Biochem. 2014;33(5):1426-38. Epub 2014 May 5. Fang ZP, Jiang BG, Gu XF, Zhao B, Ge RL, Zhang FB*. P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma. Acta Pharmacol Sin. 35(1):82-8.2014 Jan; Li Y, Yang C, Ma G, Gu X, Chen M, Chen Y, Zhao B, Cui L*, Li K*. Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene with COPD in the Chinese Population.DNA Cell Biol.33(4):1-8. 2014 Feb ; He HJ, Gu XF, Xu WH, Yang DJ, Wang XM, Su Y*. Krüppel-like factor 8 is a novel androgen receptor co-activator in human prostate cancer. Acta Pharmacol Sin. 34(2):282-8. 2013 Feb; Li Y, Cui LL, Li QQ, Ma GD, Cai YJ, Chen YY, Gu XF, Zhao B, Li KS(*).Association between ADAM17 promoter polymorphisms and ischemic stroke in a Chinese population. J Atheroscler Thromb. 21(8):878-93. Epub 2014 Apr 12. 顾雪锋; 朱大海; 赵心怡. 鸡骨骼肌表达序列标签基因芯片的制备方法（200410043662.3）[专利] 高兴春 , 顾雪锋 , 韩俊 , 朱大海. 基于电子克隆方法获得鸡MIBP 全长cDNA .生物信息学2006.2 (3): 58-61 Li KS, Gu XF,Li P . Effect of pseudolaric acid B on gastric cancer cells: Inhibition of proliferation and induction of apoptosis. World J Gastroenterol 2005; 11(48):7555-7559 Gu XF, Lee JH, Li KS, Jahng, JW. Gene Expression Profiles of As2O3-Treated Cervical Cancer Hela Cells.Proceeding of the 5th International Forum on Post-Genome Technologies. 2007;5(1)：357-360. (ISTP, UT ISIP:000251162700127). Li KS, Luan K, Gu XF, Dai DW, Zhang LW, Guo L, Tang G, Guo ZW. Genome-wide expression profile of rat's vestibular nucleus responded to coriolis using cDNA microarray analysis. Proceeding of the 5th International Forum on Post-Genome Technologies, 89-91, 2007. (ISTP, UT ISIP:000251162700043). Gu XF, Lee JH, Ryu V, Yoo SB, Moon YW, Jahng JW. Ambulatory activity and the accumbens c-Fos expression were decreased by repeated oral capsaicin in rats. 2nd International Congress of Stress Research. 23-26 August 2007,Budapest, Hungary. Li KS, Gu XF,Luan K.Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population. Neurosci Lett. 2008; 433(2):125-8. Li KS, Dong DM, Gu XF,Guo L. Identification of STC1 as an beta-amyloid activated gene in human brain microvascular endothelial cells using cDNA microarray.Biochem Biophys Res Commun. 2008;376(2):399-403. Ryu V, Lee JH,Yoo SB, Gu XF, Moon YW and Jahng JW.Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation. Int J Obes. 2008;32(9):1355-62. Gu XF, Lee JH,Yoo SB,Moon YW,Jahng JW. Intra-oral pre-treatment with capsaicin increases consumption of sweet solutions in rats.NUTR NEUROSCI2009;12(4)：149-154. Wang HB, Wang QG, Gu XF, and Li H. Microarray analysis of genes differentially expressed in the liver of lean and fat chickens. Animal (2010), 4:4, pp 513–522
基金: 《GSK3β 在GRK5 基因缺陷致AD 轴突转运缺陷中的作用机制研究》 国家自然科学基金 80 第二参与人 《miR-122对APP非淀粉样代谢途径的调节以及miR-122基因多态与阿尔茨海默病易感性关联分析》国家自然科学基金 65 第一参与人 《翻译控制肿瘤蛋白TCTP对胶质瘤细胞干性的影响及机制研究》 广东省自然科学基金 10 主持 《中药抑癌分子机理的基因芯片技术平台的建立》(批准号：2003AA2Z2051) 863重大专项计划192 第一参与人 《利用基因芯片技术对抗癌药物机理的研究》(批准号：GB03C602-3) 黑龙江省科技攻关计划项目20 主持 《抗肝癌小分子RNA新药：AZSI012候选药物研究》批准号：12431901604，上海市科技支撑项目30 主持 《2016年广东省扬帆计划》 ，12
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