岳冰
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个人信息

  • 姓名:岳冰
  • 职称:主任医师
  • 导师资格:硕士生导师
  • 学科专业:中西医结合临床
  • 联系方式:advbmp2@163.com

个人简介

岳 冰,主任医师,博士研究生导师,国家杰出青年科学基金获得者,国家重点研发计划首席科学家,上海交通大学医学院附属仁济医院副院长。现任国际华人骨研学会(ICMRS)终身会员,中华医学会运动医疗分会委员,中华医学会骨科分会关节镜学组委员,上海医学会运动医学分会副主任委员。长期聚焦于骨关节难治疾病的基础与临床转化研究。入选国家杰青、国家重点研发计划首席科学家、上海市优秀学术带头人、上海市杰出青年医学人才等人才计划。近5年以第一或通讯作者在国际相关临床及基础领域权威期刊发表SCI论文30余篇。担任《中华关节外科杂志》、《中华创伤骨科杂志》、Arthroplasty等杂志编委或特邀编委。

教育经历

2007/9- 2010/7 上海交通大学医学院 骨科学 博士 2001/9- 2004/7 上海交通大学医学院 骨科学 硕士 1996/9- 2001/7 山西医科大学 临床医学 学士

工作经历

2017/12-至今 上海交通大学医学院附属仁济医院 骨关节外科 主任医师 2016/11-2017/12 上海交通大学医学院附属仁济医院 骨关节外科 副主任医师 2013/01- 2016/11 上海交通大学医学院附属第九人民医院 骨科 副主任医师 2007/05- 2012/12 上海交通大学医学院附属第九人民医院 骨科 主治医生 2004/08- 2007/04 上海交通大学医学院附属第九人民医院 骨科 住院医师

主要科研工作与成绩

1.主持课题 (1)骨与关节感染的治疗和修复重建(82225031)(400万元), 2023/01- 2027/12, 国家杰出青年科学基金 负责人 (2)针对假体周围感染“顽固”致病菌的“新型抗菌肽/介孔二氧化硅复合生物材料”的研发及在假体周围感染翻修术中的应用研究 (82172464) (55万元), 2022/01- 2025/12, 国家自然科学基金面上项目 负责人 (3)多孔钽骨修复材料及植入性产品开发与临床应用(2020YFC1107500)(1897万), 2020/07-2023/6, 国家重点研发计划 项目总负责人 (4)新型“胞内菌特异性抗感染生物材料”的研发及在关节假体周围感染治疗中的应用研究(81972086)(55万元), 2020/01-2023/12, 国家自然科学基金面上项目 负责人 (5)“pH值响应式抗生素智能控释”多级孔氧化硅/碳纤维复合材料的研发及在关节假体周围感染翻修中的应用研究(81672196)(57万元), 2017/01-2020/12, 国家自然科学基金面上项目 负责人 (6)利用分子探针Zn-DPA定位人工全膝关节置换术后关节内感染病灶的研究(81472119)(72万元), 2015/01-2018/12, 国家自然科学基金面上项目 负责人 (7)人体膝关节体内运动的性别差异研究(30901517 )(23 万元), 2010/01-2012/12, 国家自然科学基金青年项目 负责人 (8)个性化多孔钽植入物临床应用与智能随访(20161423)(100万元), 2019/07-2022/07, 上海市教委高峰高原学科建设计划 负责人 (9)骨、软骨缺损的细胞治疗和相关生物材料研究(20161423)(100万元), 2016/07-2019/07, 上海市教委高峰高原学科建设计划 负责人 (10)3D打印多孔钽的抗菌效能及其对感染相关免疫微环境调控机制的研究(22XD1401900)(40万元)2022/09-2025/08,上海市科委 优秀学术带头人 负责人 (11)3D打印多孔钽个性化骨科内植入物的疗效评价与智能预后模型的构建(20224Z0011)(30万元)2022/01-2024/12,上海卫健委 卓越项目 负责人 (12)联合血清学指标检测骨关节相关感染的诊断效能研究(19411962800)(20万元), 2020/01-2022/12, 上海市科委 负责人 (13)后交叉韧带在全膝关节置换术后体内功能的研究(11QA1404100 )(15 万元), 2011/4-2014/4, 上海市科委 负责人 (14)全膝关节置换术对后交叉韧带功能影响的研究(XYQ2011024)(60 万元), 2012/1-2014/1, 上海市卫健委 负责人 2.科研论文 (1)Zhang S, Yang H, Wang M, Mantovani D, Yang K, Witte F, Tan L, Yue B, Qu X. Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives. Innovation. 2023;4(6):100503. doi: 10.1016/j.xinn.2023.100503. (IF: 32.1) (2)Qu X, Wang M, Wang M, Tang H, Zhang S, Yang H, Yuan W, Wang Y, Yang J, Yue B. Multi-Mode Antibacterial Strategies Enabled by Gene-Transfection and Immunomodulatory Nanoparticles in 3D-Printed Scaffolds for Synergistic Exogenous and Endogenous Treatment of Infections. Advanced Materials. 2022, 10:e2200096. doi: 10.1002/adma.202200096. (IF: 32.086) (3)Nie B, Huo S, Qu X, Guo J, Liu X, Hong Q, Wang Y, Yang J, Yue B. Bone Infection Site Targeting Nanoparticle-Antibiotics Delivery Vehicle to Enhance Treatment Efficacy of Orthopedic Implant Related Infection. Bioactive Materials. 2022, 16:134-148. doi: 10.1016/j.bioactmat.2022.02.003. (IF: 16.874) (4)Tang H, Qu X, Zhang W, Chen X, Zhang S, Xu Y, Yang H, Wang Y Yang J, Yuan W, Yue B. Photosensitizer Nanodot Eliciting Immunogenicity for Photo-Immunologic Therapy of Postoperative Methicillin-Resistant Staphylococcus Aureus Infection and Secondary Recurrence. Advanced Materials. 2022, 34(12):e2107300. doi: 10.1002/adma.202107300. (IF: 32.086) (5)Zhang S, Qu X, Jiao J, Tang H, Wang M, Wang Y, Yang H, Yuan W, Yue B. Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms. Bioactive Materials, 2021, 14:272-289. doi: 10.1016/j.bioactmat.2021.11.019. (IF: 16.874) (6)Huo S, Wang F, Lyu Z, Hong Q, Nie B, Wei J, Wang Y, Zhang J, Yue B. Dual-Functional Polyetheretherketone Surface Modification for Regulating Immunity and Bone Metabolism. Chemical Engineering Journal. 2021, 426:130806. doi: 10.1016/j.cej.2021.130806. (IF: 16.744) (7)Zhang S, Qu X, Tang H, Wang Y, Yang H, Yuan W, Yue B. Diclofenac Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactams and Prevents Implant Infections. Advanced Science. 2021, 8(13): 2100681. doi:10.1002/advs.202100681. (IF: 17.521) (8)Xu Y, Chen X, Qian Y, Tang H, Song J, Qu X, Yue B, Yuan W. Melatonin-Based and Biomimetic Scaffold as Muscle–ECM Implant for Guiding Myogenic Differentiation of Volumetric Muscle Loss. Advanced Functional Materials. 2020, 30(27):2002378. doi: 10.1002/adfm.202002378. (IF: 19.924) (9)Chen X, Ge X, Qian Y, Tang H, Song J, Qu X, Yue B, Yuan W. Electrospinning Multilayered Scaffolds loaded with Melatonin and Fe3O4 Magnetic Nanoparticles for Peripheral Nerve Regeneration. Advanced Functional Materials. 2020, 30(38): 2004537. doi: 10.1002/adfm.202004537. (IF: 19.924) (10)Gao H, Yang J, Jin X, Qu X, Zhang F, Zhang D, Chen H, Wei H, Zhang S, Jia W, Yue B, Li X, Porous tantalum scaffolds: Fabrication, structure, properties, and orthopedic applications. Materials & Design. 2021, 210:110095, doi: 10.1016/j.matdes.2021.110095. (IF: 9.417) (11)Jiao J, Hong Q, Zhang D, Wang M, Tang H, Yang J, Qu X, Yue B. Influence of porosity on osteogenesis, bone growth and osteointegration in trabecular tantalum scaffolds fabricated by additive manufacturing. Frontiers in Bioengineering and Biotechnology. 2023;11:1117954. doi: 10.3389/fbioe.2023.1117954. (IF: 6.064) (12)Jiao J, Zhang S, Qu X, Yue B. Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials. Frontiers in cellular and infection microbiology. 2021, 11:693939. doi: 10.3389/fcimb.2021.693939. (IF: 6.073) (13)Xu J, Ji J, Jiao J, Zheng L, Hong Q, Tang H, Zhang S, Qu X, Yue B. 3D Printing for Bone-Cartilage Interface Regeneration. Frontiers in Bioengineering and Biotechnology. 2022, 10:828921, doi: 10.3389/fbioe.2022.828921. (IF: 6.064) (14)Hong Q, Huo S, Tang H, Qu X and Yue B. Smart nanomaterials for treatment of biofilm in orthopedic implants. Frontiers in Bioengineering and Biotechnology. 2021, 9:694635. doi: 10.3389/fbioe.2021.694635. (IF: 6.064) (15)Huo S, Liu X, Zhang S, Lyu Z, Zhang J, Wang Y, Nie B, Yue B. p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. International Immunopharmacology. 2021, 94:107458. doi: 10.1016/j.intimp.2021.107458. (IF: 5.714) (16)Huo S, Chen C, Lyu Z, Zhang S, Wang Y, Nie B, Yue B. Overcoming Planktonic and Intracellular Staphylococcus aureus-associated Infection with a Cell-Penetrating Peptide-Conjugated Antimicrobial Peptide. ACS Infectious Diseases. 2020, 6(12):3147-3162. doi: 10.1021/acsinfecdis.0c00264. (IF: 5.578) (17)Huo S, Yue B. Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface. World Journal of Stem Cells. 2020, 12(7):545-561. doi: 10.4252/wjsc.v12.i7.545.(IF: 5.247) (18)Zhang S, Tang H, Wang Y, Nie B, Yang H, Yuan W, Qu X, Yue B. Antibacterial and antibiofilm effects of flufenamic acid against methicillin-resistant Staphylococcus aureus. Pharmacological Research. 2020, 160:105067. doi: 10.1016/j.phrs.2020.105067. (IF: 10.334) (19)Tang H, Xu J, Yuan W, Wang Y, Yue B, Qu X. Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non-Inflammatory Arthritis Periprosthetic Joint Infection: A Meta-analysis and Systematic Review. Orthop Surg. 2022;10.1111/os.13500. doi:10.1111/os.13500 (IF:2.279) (20)Li H, Jiao J, Zhang S, Tang H, Qu X, Yue B. Construction and Comparison of Predictive Models for Length of Stay after Total Knee Arthroplasty: Regression Model and Machine Learning Analysis Based on 1,826 Cases in a Single Singapore Center. The Journal of Knee Surgery. 2022, 35(1):7-14. doi:10.1055/s-0040-1710573. (IF: 2.501) (21)Li H, Zhang S, Huo S, Tang H, Nie B, Qu X, Yue B. Effects of staphylococcal infection and aseptic inflammation on bone mass and biomechanical properties in a rabbit model. Journal of Orthopaedic Translation. 2019, 21:66-72, doi: 10.1016/j.jot.2019.11.006. (IF: 4.889) (22)Zhang S, Li H, Tang H, Huo S, Nie B, Qu X, Yue B. Felodipine blocks osteoclast differentiation and ameliorates estrogen-dependent bone loss in mice by modulating p38 signaling pathway. Experimental Cell Research. 2020, 387(2):111800. doi: 10.1016/j.yexcr.2019.111800. (IF: 4.145) (23)Zhang S, Huo S, Li H, Tang H, Nie B, Qu X, Yue B. Flufenamic acid inhibits osteoclast formation and bone resorption and act against estrogen-dependent bone loss in mice. International Immunopharmacology. 2019, 106014. doi: 10.1016/j.intimp.2019.106014. (IF: 5.714) (24)Tang H, Qu X, Yue B. Diagnostic test accuracy of magnetic resonance imaging and ultrasound for detecting bone erosion in patients with rheumatoid arthritis. Clinical Rheumatology. 2020, 39(4):1283-1293. doi:10.1007/s10067-019-04825-6. (IF: 3.650) (25)Li H, Yue B. Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells. World Journal of Stem Cells. 2019, 11(6):322-336. doi: 10.4252/wjsc.v11.i6.322. (IF: 5.247) (26)Tang H, Li H, Zhang S, Wang Y, Qu X, Yue B. Postoperative Complications Causing Readmission in 30 Days after Total Knee Arthroplasty: A Retrospective Nested Case-Control Study of Risk Factors Based on Propensity Score Matching. The Journal of Knee Surgery. 2020, 33(11):1100-1108. doi: 10.1055/s-0039-1692630. (IF: 2.501) (27)Li H, Zhang S, Nie B, Long T, Qu X and Yue B. KR-12-a5 Reverses Adverse Effects of Lipopolysaccharides on HBMSC Osteogenic Differentiation by Influencing BMP/Smad and P38 MAPK Signaling Pathways. Frontiers in Pharmacology. 2019, 10:639. doi: 10.3389/fphar.2019.00639. (IF: 5.988) (28)Li H, Nie B, Zhang S, Long T, Yue B. Immobilization of type I collagen/hyaluronic acid multilayer coating on enoxacin loaded titania nanotubes for improved osteogenesis and osseointegration in ovariectomized rats, Colloids and Surfaces B: Biointerfaces. 2019, 175:409-420. doi: 10.1016/j.colsurfb.2018.12.033. (IF: 5.999) (29)Tan H, Wang Y, Long T, Nie B, Mao Z, Yue B. How to accurately determine the distal femoral valgus cut angle in the valgus knee arthroplasty. International Orthopaedics. 2018, 42(3):537-542. doi: 10.1007/s00264-018-3778-1. (IF: 3.479) (30)Yue B, Wang J, Wang Y, Yan M, Zhang J, Zeng Y. The intercondylar notch ceiling: an accurate reference for distal femoral resection in total knee arthroplasty for severely degenerated varus knees. Knee Surgery, Sports Traumatology, Arthroscopy. 2017, 25(9):2818-2824. doi: 10.1007/s00167-015-3792-4. (IF: 4.114) (31)Nie B, Long T, Li H, Wang X, Yue B. A comparative analysis of antibacterial properties and inflammatory responses for the KR-12 peptide on titanium and PEGylated titanium surfaces. RSC Advances. 2017, 7, 34321–34330. (IF: 4.036) (32)Nie B, Ao H, Teng L, Zhou J, Tang T, Yue B. Immobilizing bacitracin on titanium for prophylaxis of infections and for improving osteoinductivity: An in vivo study

主要社会学术团体兼职

1.2020 -- 至今 上海医学会运动医学分会 副主任委员 2.2020 -- 至今 国际华人骨研学会 终身会员 3.2019 -- 至今 中国医师协会运动医学医师分会 委员 4.2017 -- 至今 中华医学会骨科分会关节镜学组 委员 5.2017 -- 至今 中国医师协会骨科分会人工关节感染专业委员会 委员 6.2016 -- 至今 中国医师协会骨科分会运动医学专业委员会 委员 7.2015 -- 至今 中华医学会医学工程学分会数字骨科学组 委员 8.2015 -- 至今 SICOT(国际矫形与创伤外科学会)中国部骨科基础学会第一届委员会委员 9.2009 -- 2010 美国哈佛大学医学院华人专家学者联合会 (http://hms-cssa.org/wp/) 副主席 10.2013 -- 至今 SICOT(国际矫形与创伤外科学会)中国学会上海分委会 常委兼关节镜与运动医学学组副组长 11.2016 -- 至今 《中华关节外科杂志》编委 12.2022 -- 至今 《中华创伤骨科杂志》特邀编委 13.2017 -- 至今 《中华肩肘外科杂志》通讯编委 14.2016 -- 至今 《Arthroplasty》《Frontiers in Medicine》 编委