吴锴博士，研究领域为基于计算生物学及结构生物学的蛋白质设计，目前聚焦于医药工业相关酶分子的研究与应用。主持并参与了多项手性药物的酶催化工艺研究及基金课题研究。近五年发表SCI论文12篇，申请发明专利4项（含已授权两项）。向企业成果转化一项。论文发表在Chemical Science，Catalysis Science & Technology, Applied Microbiology and biotechnology等本领域重要期刊。

2011.9-2016.6 华东理工大学 生物化学与分子生物学 研究生 博士

2016.7-2016.12 药明康德新药研发有限公司 高级工艺研发员 2016.12-2022.12 上海健康医学院 药学院/协同科研中心 讲师 2023.1-至今 上海健康医学院 药学院副教授/曼彻斯特大学生物技术研究院 访问学者

(1) Kai Wu, Jinrong Yan, Qinde Liu, Xiaojing Wang, Piaoru Wu, Yiyang Cao, Xiuhong Lu, Yixin Xu, Junhai Huang and Lei Shao; Computational Design of an Imine Reductase: Mechanism-Guided Stereoselectivity Reversion and Interface Stabilization, Chemical Science, 2024, 1431-1440 (期刊论文) (2) Kai Wu; Zhijun Yang; Xiangguo Meng; Rong Chen; Jiankun Huang; Lei Shao ; Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reductio n of steric hindrance and change of the stereocontrol element, Catalysis Science & Technology, 20 20, 10(6): 1650-1660 (期刊论文) (3) Kai Wu; Jinrong Yan; Xiaojin Wang; Xinai Yin; GuiXiang Shi; Lei Yang; Fangling Li; Junhai Huang; Lei Shao ; Efficient synthesis of bepotastine and cloperastine intermediates using enginee red alcohol dehydrogenase with a hydrophobic pocket., Applied Microbiology and Biotechnology, 2021, 2021(105): 5873-5882 (期刊论文) (4) Jinrong Yan; xiaojing wang; Fangling Li; Lei Yang; Guixiang Shi; Weihang Sun; Lei Shao; J unhai Huang; Kai Wu ; Biocatalytic preparation of a key intermediate of antifungal drugs using an alcohol dehydrogenase with high organic tolerance, Tetrahedron Letters, 2021, 84(153455) (期 刊论文) (5) Wu Kai; Zheng Kun; Xiong Liangbin; Yang Zhijun; Jiang Zhiteng; Meng Xiangguo; Shao Lei ; Efficient synthesis of an antiviral drug intermediate using an enhanced short-chain dehydrogenase in an aqueous-organic solvent system, Applied Microbiology and Biotechnology, 2019, 103(11): 4417-4427 (期刊论文) (6) 吴锴; 邵雷; 黄军海; 闫锦荣 ; 一类亚胺还原酶突变体及其在催化合成手性2-芳基吡咯烷中的应用, 2024-3-12, 中国, CN202210475623.9 (专利) (7) 吴锴; 徐一新; 邵雷; 孟祥国; 黄剑坤 ; 醇脱氢酶突变体及其制备方法和应用, 2020-12-11, 中国, 201910244434.9 (专利) (8) 魏东芝; 王华磊; 吴锴 ; 一种环氧化物水解酶及其编码基因和应用, 2018-3-6, 中国, CN201410475055.8 (专利)

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