邬海龙，研究员，上海健康医学院协同科研中心学科带头人。毕业于美国南伊利诺伊大学，获博士学位。先后在美国约翰霍普金斯大学和美国国立健康研究院从事博士后研究。回国后在上海交通大学和中国科学院生物化学与细胞生物学研究所任副研究员。2018年就任上海健康医学院学科带头人。主要从事肿瘤发生发展相关的基础与转化研究。主持国自然面上项目三项，省部级项目多项。发表SCI论文40余篇。

2004/8 – 2009/8 美国南伊利诺伊大学，分子生物学与细胞生物学专业，博士 1994/9 – 1998/7 复旦大学，微生物，学士

2023/12 – 至今 上海健康医学院，学科带头人，课题组长，研究员 2018/9 – 2023/12 上海健康医学院，学科带头人，课题组长，副研究员 2015/7 – 2018/8 中国科学院生物化学与细胞生物学研究生所，副研究员 2012/7 – 2015/7 上海交通大学医学院附属仁济医院，干细胞中心，副研究员 2010/10 – 2012/7 美国国家健康研究院，国家癌症中心，博士后 2009/7 – 2010/10 美国约翰霍普金斯大学，公共卫生学院，博士后

科研项目 国家自然科学基金面上项目 1.Smo-Sufu调控TLR4信号通路及败血症的机制与功能研究（3187050122） 2.SET7/9甲基化转录因子GLI并调控Hedgehog信号通路的机制及功能研究（31671453） 3.生殖干细胞专有基因PIWIL2调节miR-10a抑制肿瘤及机制研究（81372233） 上海市科委面上项目 环状RNA-circUCK2竞争性结合miR-149-5p促进肝癌发生发展的机制及功能研究 （22ZR1428100） 上海市卫健委临床研究面上项目 联合用药靶向UCK2-EGFR调控轴治疗肝细胞癌的作用及机制研究 （201940352） 论文 1.Qu X, Wen Y, Jiao J, Zhao J, Sun X, Wang F, Gao Y, Tan W, Xia Q, Wu H, Kong X. PARK7 deficiency inhibits fatty acid β-oxidation via PTEN to delay liver regeneration after hepatectomy. Clin Transl Med. 2022 Sep;12(9):e1061. doi: 10.1002/ctm2.1061.  (co-corresponding author) 2.Le J, Ji H, Pi P, Chen K, Gu X, Ma Y, Fu Y, Sun Y, Zhou X, Wu H. The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells. Evid Based Complement Alternat Med. 2022 Aug 31;2022:8063497. doi: 10.1155/2022/8063497. (corresponding author) 3.Guo H, Qian Y, Yu Y, Bi Y, Jiao J, Jiang H, Yu C, Wu H, Shi Y, Kong X. An Immunity-Related Gene Model Predicts Prognosis in Cholangiocarcinoma. Front Oncol. 2022 Jul 1;12:791867. doi: 10.3389/fonc.2022.791867. (co-corresponding author) 4.Qian Y, Shang Z, Gao Y, Wu H, Kong X. Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells. Cell Mol Gastroenterol Hepatol. 2022 Jun 20;14(5):971-81. doi: 10.1016/j.jcmgh.2022.05.014. (co-corresponding author) 5.Fu Y, Wei XD, Guo L, Wu K, Le J, Ma Y, Kong X, Tong Y, Wu H. The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression. Front Oncol. 2022 May 20;12:904887. doi: 10.3389/fonc.2022.904887. (corresponding author) 6.Huang M, Jiao J, Cai H, Zhang Y, Xia Y, Lin J, Shang Z, Qian Y, Wang F, Wu H, Kong X, Gu J. CCL5 confines liver regeneration by downregulating reparative macrophage-derived HGF in an FoxO3a dependent manner. Hepatology. 2022 Mar 15. doi: 10.1002/hep.32458. 7.Le J, Ji H, Zhou X, Wei X, Chen Y, Fu Y, Ma Y, Han Q, Sun Y, Gao Y, Wu H. Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound. Front Pharmacol. 2021 Oct 26;12:714586. doi: 10.3389/fphar.2021.714586. (corresponding author) 8.Jiang Y, Peng J, Song J, He J, Jiang M, Wang J, Ma L, Wang Y, Lin M, Wu H, Zhang Z, Gao D, Zhao Y. Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2. Nat Metab. 2021 Nov;3(11):1569-1584. doi: 10.1038/s42255-021-00488-3.  9.Han QQ, Fu Y, Le JM, Ma YJ, Wei XD, Ji HL, Jiang H, Gao Y, Wu H. The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. (corresponding author) 10.Fu Y, Wei X, Han Q, Le J, Ma Y, Lin X, Xu Y, Liu N, Wang X, Kong X, Gu J, Tong Y, Wu H. Identification and characterization of a 25-lncRNA prognostic signature for early recurrence in hepatocellular carcinoma. BMC Cancer. 2021 Oct 30;21(1):1165. doi: 10.1186/s12885-021-08827-z. (corresponding author) 11.Yu C, Zhu X, Zheng C, Luo Y, Wang F, Gao Y, Wu H, Sun X, Kong X. Methyl Diet Enhanced Sepsis-Induced Mortality Through Altering Gut Microbiota. J Inflamm Res. 2021 Jul 9;14:3107-3121. doi: 10.2147/JIR.S305202. 12.Aishanjiang K, Wei XD, Fu Y, Lin X, Ma Y, Le J, Han Q, Wang X, Kong X, Gu J, Wu H. Circular RNAs and Hepatocellular Carcinoma: New Epigenetic Players With Diagnostic and Prognostic Roles. Front Oncol. 2021 Apr 20;11:653717. doi: 10.3389/fonc.2021.653717. (corresponding author) 13.Ma Y, Liu X, Wei X, Le J, Fu Y, Han Q, Ji H, Yang Z, Wu H. Yolk-Shelled Gold@Cuprous Oxide Nanostructures with Hot Carriers Boosting Photocatalytic Performance. Langmuir. 2021 Apr 20;37(15):4578-4586. doi: 10.1021/acs.langmuir.1c00198. (corresponding author) 14.Le J, Fu Y, Han Q, Ma Y, Ji H, Wei X, Chen Y, Sun Y, Gao Y, Wu H. Transcriptome Analysis of the Inhibitory Effect of Sennoside A on the Metastasis of Hepatocellular Carcinoma Cells. Front Pharmacol. 2021 Jan 12;11:566099. doi: 10.3389/fphar.2020.566099. (corresponding author) 15.Han QQ, Fu Y, Le JM, Pilot A, Cheng S, Chen PQ, Wu H, Wan GQ, Gu XF. Electroacupuncture may alleviate behavioral defects via modulation of gut microbiota in a mouse model of Parkinson's disease. Acupunct Med. 2021 Oct;39(5):501-511. doi: 10.1177/0964528421990658.  16.Cai J, Sun X, Guo H, Qu X, Huang H, Yu C, Wu H, Gao Y, Kong X, Xia Q. Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma. Oncogenesis. 2020 Dec 4;9(12):103. doi: 10.1038/s41389-020-00287-7. 17.Zhang S, Zhao J, Lv X, Fan J, Lu Y, Zeng T, Wu H, Chen L, Zhao Y. Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila. Cell Discov. 2020 Jun 30;6:43. doi: 10.1038/s41421-020-0173-z. 18.Liu N, Sun Q, Wan L, Wang X, Feng Y, Luo J, Wu H. CUX1, A Controversial Player in Tumor Development. Front Oncol. 2020 May 29;10:738. doi: 10.3389/fonc.2020.00738. (corresponding author) 19.Wan G, Zhu J, Gu X, Yang Y, Liu Y, Wang Z, Zhao Y, Wu H, Huang G, Lu C. Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription. Br J Cancer. 2020 Aug;123(4):633-643. doi: 10.1038/s41416-020-0873-z. (co-corresponding author) 20.Li J, Zhao J, Xu M, Li M, Wang B, Qu X, Yu C, Hang H, Xia Q, Wu H, Sun X, Gu J, Kong X. Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia-reperfusion injury. Cell Death Dis. 2020 Apr 17;11(4):244. doi: 10.1038/s41419-020-2437-9. 21.Guo H, Cai J, Wang X, Wang B, Wang F, Li X, Qu X, Kong X, Gao Y, Wu H, Sun X, Xia Q, Kong X. Prognostic values of a novel multi-mRNA signature for predicting relapse of cholangiocarcinoma. Int J Biol Sci. 2020 Jan 16;16(5):869-881. doi: 10.7150/ijbs.38846.  22.Chen L, Gu J, Qian Y, Li M, Qian Y, Xu M, Li J, Wen Y, Xia L, Li J, Xia Q, Kong X, Wu H. Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity. Cell Mol Gastroenterol Hepatol. 2019;7(3):623-639. doi: 10.1016/j.jcmgh.2018.12.009. (corresponding author) 23.Fan J, Gao Y, Lu Y, Wu W, Yuan S, Wu H, Chen D, Zhao Y. PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila. Cell Discov. 2019 Sep 10;5:44. doi: 10.1038/s41421-019-0112-z. 24.Li M, Sun X, Zhao J, Xia L, Li J, Xu M, Wang B, Guo H, Yu C, Gao Y, Wu H, Kong X, Xia Q. CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization. Cell Mol Immunol. 2020 Jul;17(7):753-764. doi: 10.1038/s41423-019-0279-0.  (co-corresponding author) 25.Cai J, Tong Y, Huang L, Xia L, Guo H, Wu H, Kong X, Xia Q. Identification and validation of a potent multi-mRNA signature for the prediction of early relapse in hepatocellular carcinoma. Carcinogenesis. 2019 Jul 20;40(7):840-852. doi: 10.1093/carcin/bgz018. (co-corresponding author) 26.Li M, Xu M, Li J, Chen L, Xu D, Tong Y, Zhang J, Wu H, Kong X, Xia Q. Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice. J Immunol Res. 2018 Dec 24;2018:9807139. doi: 10.1155/2018/9807139. (co-corresponding author) 27.Xu D, Xu M, Jeong S, Qian Y, Wu H, Xia Q, Kong X. The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches. Front Pharmacol. 2019 Jan 8;9:1428. doi: 10.3389/fphar.2018.01428. (co-corresponding author) 28.Huang L, Cai J, Guo H, Gu J, Tong Y, Qiu B, Wang C, Li M, Xia L, Zhang J, Wu H, Kong X, Xia Q. ID3 Promotes Stem Cell Features and Predicts Chemotherapeutic Response of Intrahepatic Cholangiocarcinoma. Hepatology. 2019 May;69(5):1995-2012. doi: 10.1002/hep.30404.  (co-corresponding author) 29.Xu M, Wu H, Li M, Wen Y, Yu C, Xia L, Xia Q, Kong X. DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice. Int J Biol Sci. 2018 Oct 20;14(13):1892-1900. doi: 10.7150/ijbs.28620. (co-first author) 30.Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y. Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila. J Mol Cell Biol. 2018 Oct 1;10(5):475-478. doi: 10.1093/jmcb/mjy009. (co-corresponding author) 31.Wen Y, Wang C, Gu J, Yu C, Wang K, Sun X, Sun Y, Wu H, Tong Y, Xia Q, Kong X. Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin. Cell Mol Immunol. 2019 May;16(5):483-494. doi: 10.1038/s41423-018-0033-z. 32.Wang C, Tong Y, Wen Y, Cai J, Guo H, Huang L, Xu M, Feng M, Chen X, Zhang J, Wu H, Kong X, Xia Q. Hepatocellular Carcinoma-Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element-Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth. Hepatology. 2018 Nov;68(5):1833-1850. doi: 10.1002/hep.30030. (co-corresponding author) 33.Yu C, Wang X, Huang L, Tong Y, Chen L, Wu H, Xia Q, Kong X. Deciphering the Spectrum of Mitochondrial DNA Mutations in Hepatocellular Carcinoma Using High-Throughput Sequencing. Gene Expr. 2018 May 18;18(2):125-134. doi: 10.3727/105221618X15185539348147. 34.Lv X, Chen H, Zhang S, Zhang Z, Pan C, Xia Y, Fan J, Wu W, Lu Y, Zhang L, Wu H, Zhao Y. Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci). J Mol Cell Biol. 2018 Oct 1;10(5):437-447. doi: 10.1093/jmcb/mjy008.  (co-corresponding author) 35.Pan C, Xiong Y, Lv X, Xia Y, Zhang S, Chen H, Fan J, Wu W, Liu F, Wu H, Zhou Z, Zhang L, Zhao Y. UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO Rep. 2017 Nov;18(11):1922-1934. doi: 10.15252/embr.201643289. 36.Xu D, Chen L, Chen X, Wen Y, Yu C, Yao J, Wu H, Wang X, Xia Q, Kong X. The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy. Cell Death Dis. 2017 Aug 10;8(8):e2983. d

1、上海市生物化学与分子生物学学会理事 2、Frontiers in Pharmacology, Frontiers in Oncology编委成员