林丹，女，上海健康医学院口腔医学技术专业讲师、硕导，生物医用材料博士、口腔基础医学博士后，主要研究方向包括骨修复材料、骨再生、口腔材料、数字化口腔医学技术、口腔医学有限元分析等。先后主持上海市扬帆计划、中国博士后科学基金特别资助、国家自然科学基金等多项科研项目。近五年一作/通讯发表SCI论文11篇，其中IF>10的8篇，影响因子总和150。以人为本，亦师亦友，研究方向丰富多样，课题方向选择可契合学生个人发展，愿与学生共同成就，合作共赢。

2012/9 – 2018/6 华东理工大学，材料学院，博士

2018/7 – 2021/8 上海交通大学医学院附属第九人民医院，博士后2021/9 – 今 上海健康医学院，医学技术学院，讲师/硕导

科研项目 [1]国家自然科学基金委员会，青年项目，32201104，干细胞源外泌体/介孔生物玻璃支架促进老龄骨再生及其转录组学作用机制研究，2023/01-2025/12，30万元，在研，主持[2]上海市科学技术委员会，地方院校能力建设项目，22010502600，AI赋能下的骨质疏松精准诊疗及口腔植骨材料辅助康复，2022/03-2025/02，40万，在研，参与[3]中国博士后科学基金，第13批特别资助（站中），2020T130422，促成骨的干细胞源外泌体筛选、应用及其基于lncRNA-miRNA-mRNA共表达网络的机制研究，2020/08 至 2021/08，18万元，结题，主持[4]国家自然科学基金委员会，面上项目，81970973，核壳梯度粘弹性PEGS/MBG双相支架引导髁突缺损原位一体化修复再生的基础应用研究，2020/01-2023/12，55万元，已结题，参与[5]上海市科学技术委员会，青年科技英才扬帆计划，19YF1425500，3D打印与自组装相结合构建多级微纳仿生骨修复支架，2019/05-2022/04，20万元，已结题，主持论文发表[1]Wang Z, Lao A, Huang X, Zhou Y*, Steve GF Shen*, Lin D*. Apt-19s-Functionalized 3D-Printed Mesoporous Bioactive Glass Scaffold Promotes BMSC Recruitment in Bone Regeneration via SDF-1α/CXCR4 Axis and MAPK Signaling. Advanced Functional Materials, 2024, 2316675. (IF: 19.924)[2]Ma M, Shen W, Li B, Sun M, Lin D*, Meng L*. Optimization of a concentrated growth factor/mesoporous bioactive glass composite scaffold and its application in rabbit mandible defect regeneration. Biomater. Sci., 2023,11, 6357-6372. (IF: 7.590)[3]Shi Y, Wang J, Ma C, Shen J, Dong X*, Lin D*. A Systematic Review of the Accuracy of Digital Surgical Guides for Dental Implantation. International Journal of Implant Dentistry, 2023, 9:38. (IF: 2.76)[4]Qi L, Ge W, Pan C, Jiang W, Lin D*, Zhang L*. Compromised osteogenic effect of exosomes internalized by senescent bone marrow stem cells via endocytoses involving clathrin, macropinocytosis and caveolae. Front Bioeng Biotechnol. 2023 Jan 4;10:1090914. (IF: 6.064)[5]Wang Z, Lin D*, Wang M, et al. Seamless route of self-assembly and 3D printing to fabricate hierarchical mesoporous bioactive glass scaffold for customized bone regeneration with enhanced efficacy. Chemical Engineering Journal, 2022, 446, 137270. (IF: 16.744) [6]Zhao H#, Wang X#, Jin A, Wang M, Wang Z, Huang X, Dai J*, Wang X*, Lin D*, Steve GF Shen*. Reducing relapse and accelerating osteogenesis in rapid maxillary expansion using an injectable mesoporous bioactive glass/fibrin glue composite hydrogel. Bioactive Materials, 2022, 18:507-525. (IF: 16.874)[7]Cai B#, Lin D#*, Li Y#, et al. N2-polarized neutrophils guide BMSC recruitment and initiate bone regeneration: A missing piece of the bone regeneration puzzle. Advanced Science, 2021, 2100584. (IF: 17.521)[8]Liu A, Lin D *, Zhao H, et al. Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor-activated Smad pathway. Biomaterials, 2021, 120718. (IF: 15.304)[9]Wang X#, Zhao H#, Liu Z, Wang Y, Lin D, et al. Polydopamine nanoparticles as dual-task platform for osteoarthritis therapy: a scavenger for reactive oxygen species and regulator for cellular powerhouses. Chemical Engineering Journal, 2021, 417, 129284. (IF: 16.744)[10]Lin D#, Cai B#, Wang L, et al. A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in full-thickness osteochondral defect. Biomaterials, 2020, 253, 120095. (IF: 15.304)[11]Lin D, Chai Y, Ma Y, et al. Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold. Biomaterials, 2019, 196, 122-137. (IF: 15.304)[12]Lin D, Zhang J, Bai F, et al. Fabrication and clinical application of easy-to-operate pre-cured CPC/rhBMP-2 micro-scaffolds for bone regeneration. American Journal of Translational Research, 2016, 8(3), 1379-1396. (IF: 3.94)[13]Lin D, Yang K, Tang W, et al. A poly(glycerol sebacate)-coated mesoporous bioactive glass scaffold with adjustable mechanical strength, degradation rate, controlled-release and cell behavior for bone tissue engineering. Colloids & Surfaces B Biointerfaces, 2015, 131, 1-11. (IF: 5.999)[14]Huang J, Lin D, Wei Z, et al. Parathyroid Hormone Derivative with Reduced Osteoclastic Activity Promoted Bone Regeneration via Synergistic Bone Remodeling and Angiogenesis. Small, 2020, 1905876. (IF: 15.153)[15]Tang W, Lin D, Yu Y, et al. Bioinspired trimodal macro/micro/nano-porous scaffolds loading rhBMP-2 for complete regeneration of critical size bone defect. Acta Biomaterialia, 2016, 32, 309-323. (IF: 10.633)[16]Cai L, Lin D, Chai Y, et al. MBG scaffolds containing chitosan microspheres for binary delivery of IL-8 and BMP-2 for bone regeneration. Journal of Materials Chemistry B, 2018, 6, 4453-4465. (IF: 7.571)[17]Chai Y, Lin D, Ma Y, et al. RhBMP-2 loaded MBG/PEGylated poly(glycerol sebacate) composite scaffolds for rapid bone regeneration. Journal of Materials Chemistry B, 2017, 5, 4633-4647. (IF: 7.571)[18]Niu H, Lin D, Tang W, et al. Surface topography regulates osteogenic differentiation of MSCs via crosstalk between FAK/MAPK and ILK/β-catenin pathways in a hierarchically porous environment. ACS Biomaterials Science & Engineering, 2017, 3, 3161-3175. (IF: 5.395)[19]Yuan Y, Lin D, Chen F, et al. Clinical translation of biomedical materials and the key factors towards product registration. Journal of Orthopaedic Translation, 2014, 2(2), 49-55. (IF: 4.889)[20]Zhang J, Ma X, Lin D, et al. Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism. Biomaterials, 2015, 53, 251-264. (IF: 15.304)[21]Tang W, Yuan Y, Lin D, et al. Kaolin-reinforced 3D MBG scaffolds with hierarchical architecture and robust mechanical strength for bone tissue engineering. Journal of Materials Chemistry B, 2014, 2(24), 3782-3790. (IF: 7.571)[22]Yu Y, Chen J, Chen R, Tang W, Lin D, et al. Enhancement of VEGF-Mediated Angiogenesis by 2-N,6-O-Sulfated Chitosan-Coated Hierarchical PLGA Scaffolds. ACS Applied Materials & Interfaces, 2015, 7(18), 9982-9990. (IF: 10.383)[23]Wang X, Kwak K J, Yang Z, Lin D, et al. Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma. Plos One, 2018, 13(6), e0198552. (IF: 3.752)[24]Ma Y, Huang B, Lin D, et al. Bioactivation of Calcium Phosphate Cement by Growth Factors and Their Applications. Developments and Applications of Calcium Phosphate Bone Cements. 2018.[25]赵涵江, 王泽莹, 林丹, 沈国芳. 纤维蛋白凝胶对上颌扩弓成骨矿化的影响. 中国口腔颌面外科杂志, 2021, 19(5):8.授权专利[1]林丹, 一种3D打印自组装的介孔生物玻璃多孔支架的方法. CN202210571078.3 [2]林丹, 一种采用高粘度溶胶3D打印介孔生物玻璃支架的方法. CN202210572368.X. [3]刘昌胜, 林丹, 柴延军, 袁媛. 人骨形态发生蛋白-2复合材料及其制备方法和应用, CN201610392378.X.[4]刘昌胜, 林丹, 杨凯, 袁媛. 一种介孔生物玻璃/聚癸二酸甘油酯复合支架及其制备方法和应用, CN2015101075743.刘昌胜, 袁媛, 唐为, 林丹, 牛浩一. 高强度多级微纳结构硅基骨修复支架材料、其制备方法及应用, CN2013107238158.

无